ONC201
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Non selective compound
Intended target=Induction of TRAIL pathway (PMID: 23390247); subsequent publications indicate ONC201's antitumor activity is due to TRAIL-dependent and -independent mechanisms, including the induction of a cellular stress response (PMIDs: 26884599, 26884600, 28423492, 28424227, 28700333).