Onalespib

Inhibitor of HSP90AA1, HSP90AB1

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

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Probe Onalespib is in the process of SERP review.

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Information

Protein target names: HSP90AA1, HSP90AB1

Mechanism of action: Inhibitor

Recommended in-cell concentration:

30 nM

Reviewer recommended in-cell concentration: 10 - 100 nM

Primary References:

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Secondary References:

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Probe Availability:

In Vitro Validations

Uniprot ID: P07900

Target Class: Other post-translational modification

Target SubClass: Chaperone

Potency: Kd

Potency Value: 0.71 nM

Potency Assay: ITC

PDB ID for probe-target interaction (3D structure): 2XJX

Structure-activity relationship: yes

Target aliases:

Heat shock protein HSP 90-alpha, HSPCA, HSPC1, HSP ...

DOI Reference: 10.1021/jm100060b

In Cell Validations

In Vivo Data

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

Onalespib appears to be a selective HSP90 inhibitor with good pharmacological properties that permit in vivo dosing.

(last updated: 3 Jan 2022 )