Inhibitor of HSP90AA1, HSP90AB1



Protein target names: HSP90AA1, HSP90AB1

Mechanism of action: Inhibitor

Recommended in-cell concentration:
30 nM

Reviewer recommended in-cell concentration: 10 - 100 nM

Secondary References:

In Vitro Validations

Uniprot ID: P07900
Target Class: Other post-translational modification
Target SubClass: Chaperone
Potency: Kd
Potency Value: 0.71 nM
Potency Assay: ITC
PDB ID for probe-target interaction (3D structure): 2XJX
Structure-activity relationship: yes
Target aliases:
Heat shock protein HSP 90-alpha, HSPCA, HSPC1, HSP ...

DOI Reference: 10.1021/jm100060b

In Cell Validations

In Vivo Data

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SERP ratings and comments

SERP Ratings

In Cell Rating
In Model Organisms

SERP Comments:

Onalespib appears to be a selective HSP90 inhibitor with good pharmacological properties that permit in vivo dosing.

(last updated: 3 Jan 2022 )