Ogerin

Positive allosteric Modulator of GPR68

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe Ogerin is in the process of SERP review.

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Information

GPR68

Positive allosteric

up to 1 uM

DOI - 10.1038/nature15699

Additional Data

SGC image SGC Chemical Probe Collection

Probe Availability:

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Screened for radioligand binding modulation of CNS GPCRs and toxic pharmacological off-targets. Minimal activity at all targets (pKi > 7)

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

Ogerin has moderate affinity at two GPCRs, 5-HT2B and the A2A receptor.

(last updated: 18 Oct 2020 )