NUAK1-IN-2 |
NUAK1-IN-2 : Inhibitor of NUAK1
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| NUAK1 |
|
|
up to 1 uM
Selectivity
In Vitro Selectivity Assessment
Selectivity Assessment Description:
9 fold selective over NUAK2 (IC50 30 nM ADP-Glo Assay)
In Vitro Selectivity Assessment
Potency Assay Off-Target:
ADP-Glo Assay
Selectivity Assessment Description:
Selectivity assessed over MARK1 (2858x), MARK2 (4898x), MARK3 (1905x), MARK4 (3981x) and AMPKA (2818 ...
In Vitro Selectivity Assessment
Potency Assay Off-Target:
Kinase selectivity screening at 1 uM against a general kinase panel of 140 targets in radiometric fi ...
Potency Cellular
In Vitro
NUAK1
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acsmedchemlett.4c00579
In Vivo Validations
Mouse
Dose: 5 mg/Kg
Route of delivery:
Intraperitoneal
Plasma half life:
0.7 h
Cmax:
220 ng/mL [Brain] at 30 min
Area Under the Curve::
365 hr·ng/mL
Target engagement assay:
Coadministered with ON123300 (Unsuitable) in a mouse PK cassette.
DOI Reference: 10.1021/acsmedchemlett.4c00579
Chemical Information
| Molecular Formula | C24H30N6O |
| SMILEs | CN1C2CC1CN(c1ccc(Nc3ncc4ccn(CC5CCOCC5)c4n3)cc1)C2 |
| InChI | InChI=1S/C24H30N6O/c1-28-21-12-22(28)16-30(15-21)20-4-2-19(3-5-20)26-24-25-13-18-6-9-29(23(18)27-24)14-17-7-10-31-11-8-17/h2-6,9,13,17,21-22H,7-8,10-12,14-16H2,1H3,(H,25,26,27) |
| Molecular weight | 418.25 Da |
| AlogP | 3.494200000000002 |
| HBond acceptors | 7 |
| HBond donors | 1 |
| Atoms | 61 |
| PAINS * | Yes |
* This is an automated alert only, and may not necessarily indicate an issue with this probe. ( Learn more about PAINS )