NMS-873
Allosteric Inhibitor of VCP
Structure
In Cells
In Model Organisms
Probe NMS-873 is in the process of SERP review.
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Information
Protein target names: VCP
Mechanism of action: Allosteric Inhibitor
In Vitro Validations
In Cell Validations
In Vivo Data
No in Vivo Validations
SERP ratings and comments
SERP Ratings
Comments:
Limited selectivity data (AAA ATPase, HSP90 and 53 kinases) and no wide ligand profiling data. The high lipophilicity of the compound is a concern regarding off-target selectivity. No data regarding in-cell occupancy of VCP and its relation to the biomarkers or antiproliferation phenotype that might describe the shift in potency from 30 nM in vitro.
(last updated: 19 Sept 2021 )
SERP Ratings
Comments:
(last updated: 28 Sept 2021 )