NGB2904

NGB2904 : Antagonist of DRD3

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(2 ratings)

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Probe NGB2904 is in the process of SERP review.

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Information

DRD3

Antagonist

up to 1 uM
Reviewer recommended concentration: 10-100 nM

Probe Availability:

In Vitro Validations

Uniprot ID: P35462

Target Class: GPCR

Target SubClass: Dopamine receptor

Potency: Ki

Potency Value: 1.4 ± 0.6 nM

Potency Assay: Radioligand binding assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

D(3) dopamine receptor, DRD3, DRD3_HUMAN, Dopamine ...

DOI Reference: 10.1016/S0960-894X(98)00469-7

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Selectivity within family: greater than 150-fold selectivity over all other dopamine receptor subtypes. Outside target family: A global receptor screen (Panlabs) indicated no inhibition of greater than 50% at 1 mM.

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 16 Nov 2023 )

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

Based on the original report and other published literature (eg: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771110/pdf/CNS-13-240.pdf.) NGB2904 has off target activity on D2, alpha1 and 5HT2 receptors. For example Yuan et al 1998: at Ki values of 217nM, 642nM and 223nM respectively.

(last updated: 28 Dec 2023 )