News

June 14, 2016

On Jun 30, 2016, we are relaunching The Chemical Probes Portal. The new site will feature a new user interface, new navigation, a robust database with in cell and/or in vivo validation data for the ~100 existing probes on the portal, as well as expert recommendations for selecting and applying these probes according to best practices.

June 13, 2016

The Chemical Probes Portal proudly announces its founding Board of Directors: Mark Bunnage (Pfizer), Aled Edwards (SGC), Yung Lie (Damon-Runyon Cancer Research Foundation), Herbert Waldmann (Max Planck Institute of Molecular Physiology), Tim Willson (SGC UNC), and Paul Workman (ICR).

June 10, 2016

The Chemical Probes Portal is now accepting applications for experts to join our Scientific Advisory Board (SAB). Are you an expert in medicinal chemistry, pharmacology, or chemical biology? Are you passionate about chemical probes, how they are validated, and how they are applied in research? If so, we want to hear from you!

June 8, 2016

What is a chemical probe?  A chemical probe is simply a reagent—a selective small-molecule modulator of a protein’s function—that allows the user to ask mechanistic and phenotypic questions about its molecular target in cell-based or animal studies. Importantly, a chemical probe is not a key that interacts with only one lock (the protein target) in a cell no matter what concentration it is applied. It is a molecule that is governed by the same rules of chemistry as any other; therefore, experiments using chemical probes must be designed and interpreted with care.

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