We were awed this week when scientists reported the discovery of seven earth-like planets just 39 light-years away. This discovery highlights just how many exciting things remain for us to discover and explore. While discoveries of this magnitude are rare and should be celebrated, we believe it’s also important to celebrate the incremental achievements that make such awesome discoveries possible.
February 24, 2017
February 17, 2017
The Chemical Probes Portal is excited to announce a growth campaign focusing on the Bromodomain and BCL2 family proteins. These classes of proteins are known to contain important drug targets, particularly for cancer, and have seen a lot of chemical probe activity.
Bromodomains are epigenetic proteins that ‘read’ information conveyed through chromatin modifications by binding to acetylated histones. Through the recruitment of protein partners, these proteins impact gene expression.
February 10, 2017
February 3, 2017
January 27, 2017
This month, we updated our PARP inhibitor records based on a new and important publication reporting potency and selectivity information for 11 PARP family inhibitors that are commonly used as chemical probes (Thorsell et al., 2016). This paper reports several key new observations about the activity of these inhibitors, prompting us to revisit and update the probe and historic compound records.
January 13, 2017
The Chemical Probes Portal is excited to announce a growth campaign focusing on the Tyrosine Kinases. This class of proteins is already known to contain important drug targets, as the class includes many growth factor receptors that drive tumor growth. Tyrosine kinases come in two basic flavors, receptor and non-receptor kinases, and not all of them have been well studied.
January 10, 2017
Portal News is now available http://eepurl.com/cwOnAf. In this issue, we highlight how the rigorous application of chemical probes in biological systems can lead to better probes and improve drug discovery efforts through a case study of ABT-199 (venetoclax). We also highlight two programs that we rolled out late in 2016: Historic Compounds and Vendor Links.
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December 12, 2016
The Portal now features a new class of compounds called Historic Compounds. These small molecules are typically non-selective or not sufficiently potent compared with other available chemical probes to merit the probe designation.
October 24, 2016
This guest post by Ellen Berg defines a new initiative for the Portal - a chemical probe collection that is suitable for characterizing phenotypic screens - and will be formalized soon as a Portal Resource that will be maintained and updated with guidance from a subcommittee of our Scientific Advisory Board.
October 20, 2016
We are pleased to announce the publication of new chemical probes in the Portal. We have recently released validation data for the probes listed below. These probes are still under review by our SAB so it will take a few weeks for ratings and recommendations to emerge. Stay tuned, as we will be releasing more probes as well as inviting new submissions soon!