Chemical Probes, small molecules designed to specifically modulate protein functions, are useful tools to study biological processes. PROTACS are hybrid molecule chimera which comprise a ligand and a peptide recognition motif for an E3 ligase. One side is targeting the protein of interest, the other draws in the target protein for ubiquitination and destruction by the proteasome.
October 11, 2020
August 10, 2020
Both the Chemical Probes Portal and the Probe Miner resource have been recommended in an excellent new review in Nature Reviews Genetics on the topic of discovering and validating gene dependencies in cancer cells.
June 30, 2020
June 19, 2020
To mark its fifteenth anniversary, the latest issue of Nature Chemical Biology (Volume 16 Issue 6, June 2020) has named a selection of papers they describe as their ‘Greatest Hits’ over the last five years.
We feel honoured that one of the selected papers is the Arrowsmith et al Commentary that highlighted the ‘promise and perils of chemical probes’ and announced the launch of the Chemical Probes Portal — described as a ‘a community-driven wiki resource to improve quality and convey current best practice.’
August 11, 2017
July 25, 2017
The Portal was founded as an independent organization in February of 2016. Nearly a year and a half later, I offer some reflections on the initiative: I present the rationale for why we insist on data transparency, why we did not adopt strict probe validation criteria, and why I believe the Portal can help improve the quality of the scientific literature even if our experts (Scientific Advisory Board, SAB) never agree on what makes a compound a chemical probe.
July 9, 2017
Today, an important Perspective was published in Cancer Cell (Choose and use your chemical probe wisely to explore cancer biology). The Perspective highlights both the importance of chemical probes in biomedical research and the unfortunate pollution of scientific literature that occurs when these compounds are misused.
June 20, 2017
How a $150 mistake can cost the scientific community billions
April 21, 2017
Visit our new Facebook page to keep up with Portal initiatives and updates. Friend us so you can give us feedback on how we are doing and help us grow the site to better meet your research needs. We look forward to engaging with our users through this networking platform.
April 10, 2017
Our crisis in research reproducibility is here to stay, unless we get serious about changing a culture that promotes sloppy research. While much that has been written about the reproducibility crisis emphasizes problems with contaminated cells lines, low quality antibodies and insufficiently powered studies using animal models, any good chemical biologist can identify hundreds if not thousands of studies with small molecules that are also problematic.