MSD-CYP11B2

Human CYP11B1: IC50 = 142 nM (Assay using V79 cell lines); 61x more selective for CYP11B2 compared to CYP11B1 human CYP19A1: IC50 = 1021 nM Outside target family: Closest off-targets (Panlabs): ADRA2B: IC50 = 4.7 µM @ 10 µM; HTR2B: IC50 = 5.33 µM @ 10 µM; ADRB1: IC50 = 9.62 µM @ 10 µM; Shows off-target activity in the GPCR scan on the same targets as the Panlabs screen: ADRA2C (Ki = 625.6 nM), ADRA2B (Ki = 1439.13 nM), HTR2B (Ki = 1537.45 nM), ADRB1 (Ki = 2370.28 nM), ADRA2A (Ki = 2606.75 nM)