MSC778

MSC778 : Inhibitor of FEN1

Structure

SERP Rating

Probe MSC778 is in the process of SERP review.

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Information

FEN1

Inhibitor

up to 1 uM

In Vitro Validations

Uniprot ID: P39748

Target Class: Enzyme

Target SubClass: Endonuclease

Potency: IC50

Potency Value: 3.0 nM

Potency Assay: Fluorescently labeled 5′-flap cleavage assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Flap endonuclease 1, RAD2, FEN1, FEN1_HUMAN, hFEN- ...

DOI Reference: 10.1021/acs.jmedchem.5c01526

Uniprot ID: P39748

Target Class: Enzyme

Target SubClass: Endonuclease

Potency: Kd

Potency Value: 2.9 nM

Potency Assay: SPR

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Flap endonuclease 1, RAD2, FEN1, FEN1_HUMAN, hFEN- ...

DOI Reference: 10.1021/acs.jmedchem.5c01526

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Selectivity against other nucleases: EXO1 145-fold GEN1 516-fold XPG 65-folda

Probe Selectivity in Vitro:

MSC778 displayed excellent selectivity against all members of an in-house panel of the broader nuclease superfamily, with MRE11 being the next closest in activity (>1000-fold selectivity).

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SERP ratings and comments

No SERP comments found for MSC778