MS4078

MS4078 : Degrader (PROTAC) of ALK

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

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Information

Degrader (PROTAC)

100 nM

Probe Availability:

In Vitro Validations

Uniprot ID: Q9UM73

Target Class: Kinase

Target SubClass: TK

Potency: Kd

Potency Value: 19 nM

Potency Assay: Competitive binding assay using DNA tag labeled ALK

PDB ID for probe-target interaction (3D structure): --

Target aliases:

ALK tyrosine kinase receptor, ALK, ALK_HUMAN, Anap ...

DOI Reference: 10.1016/j.ejmech.2018.03.071

In Cell Validations

In Vivo Data

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SERP ratings and comments

SERP+ Ratings

In Cell Rating

In Model Organisms

SERP+ Comments:

Although the PROTAC shows ALK degradation, it lacks selectivity assessment, so insufficient data is provided to conclude this is a selective probe for ALK. Proteosome dependent degradation has been confirmed by competition with the cereblon binder and partial competition by target warhead. Moreover, the compound has not been tested above 100nM so that the concentration at which the hook effect occurs has not been determined.

(last updated: 6 Feb 2026 )