MRK-A

MRK-A : Inhibitor of TEAD1

Structure

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Information

TEAD1

Inhibitor

up to 100 nM

In Vitro Validations

Uniprot ID: P28347

Target Class: Epigenetic

Target SubClass: Transcription Factor

Potency: ΔTm

Potency Value: 9.65

Potency Assay: Thermal Shift Assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Transcriptional enhancer factor TEF-1, TEF1, TCF13 ...

DOI Reference: 10.1021/acs.jmedchem.5c02997

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): The activity of MRK-A was profiled in Eurofins Cerep PanLab panel (Total number of assays: 108) using the Eurofins PanLab service. MRK-A exhibited < 50% inhibition of all enzymes tested at 10 µM.

Potency assay (off target): MRK-A was assessed against a panel of 247 Kinases @ 10 uM

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