MLT-748

Allosteric inhibitor of MALT1

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(0 ratings)

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Probe MLT-748 is in the process of SERP review.

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Information

MALT1

Allosteric inhibitor

up to 2 uM

Probe Availability:

MedChemExpress

In Vitro Validations

Uniprot ID: Q9UDY8

Target Class: Other

Target SubClass: Peptidase C14B

Potency: IC50

Potency Value: 5 nM

Potency Assay: MALT1 peptide cleavage inhibition

PDB ID for probe-target interaction (3D structure): 6H4A

Structure-activity relationship: yes

Target aliases:

Mucosa-associated lymphoid tissue lymphoma translo ...

DOI Reference: 10.1038/s41589-018-0222-1

Uniprot ID: Q9UDY8

Target Class: Other

Target SubClass: Peptidase C14B

Potency: Kd

Potency Value: 42 nM

Potency Assay: SPR for WT

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Mucosa-associated lymphoid tissue lymphoma translo ...

DOI Reference: 10.1038/s41589-018-0222-1

Uniprot ID: Q9UDY8

Target Class: Other

Target SubClass: Peptidase C14B

Potency: Kd

Potency Value: 13 nM

Potency Assay: SPR for mutant W580S

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Mucosa-associated lymphoid tissue lymphoma translo ...

DOI Reference: 10.1038/s41589-018-0222-1

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

MLT-748 does not show inhibitory activity on any of 22 other tested human proteases with IC50 values >100 μM

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SERP ratings and comments

SERP Ratings

In Cell Rating

(last updated: 4 Aug 2021 )