ML352

ML352 : Non Competitive Inhibitor of SLC5A7

Structure

SERP Rating

Probe ML352 is in the process of SERP review.

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Information

SLC5A7

Inhibitor

up to 1 uM

Probe Availability:

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

ML352 was tested in Eurofin’s Lead Profiling Screen which is a binding assay panel of 68 GPCR’s, ion channels and transporters screened at 10 μM. ML352 did not show any significant inhibition of any of the targets (significant activity constitutes >50% inhibition at 10 μM), highlighting a clean ancillary pharmacology profile. In addition, ML352 was tested against the dopamine transporter (DAT) and did not show any inhibitory activity at the highest concentration tested. no inhibition of Cytochrome P450 1A2, 2C9, 2D6 or 3A4 at concentrations up to 30 µM.

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SERP ratings and comments

No SERP comments found for ML352