MCC950
MCC950 : Inhibitor of NLRP3
Structure
In Cells
In Model Organisms
Probe MCC950 is in the process of SERP review.
Please continue to check back for new reviews and commentary.
SERP ratings and comments
SERP Ratings
SERP Comments:
This probe has been tested in human primary cell-based assays (BioMAP Diversity PLUS panel from Eurofins Discovery) at 370 – 10 uM. Selectively active in only one of the 12 assay systems at 370 nM, 1.1 uM and 3.3 uM. Activity is restricted to the BioMAP LPS system, a co-culture stimulated with LPS, so consistent with the target. It was not active in a system containing differentiated macrophages stimulated through TLR2.
(last updated: 15 Sept 2020 )
SERP Ratings
(last updated: 6 Jul 2022 )