MCC950
MCC950 : Inhibitor of NLRP3
Structure
In Cells
In Model Organisms
SERP ratings and comments
SERP Ratings
SERP Comments:
This probe has been tested in human primary cell-based assays (BioMAP Diversity PLUS panel from Eurofins Discovery) at 370 – 10 uM. Selectively active in only one of the 12 assay systems at 370 nM, 1.1 uM and 3.3 uM. Activity is restricted to the BioMAP LPS system, a co-culture stimulated with LPS, so consistent with the target. It was not active in a system containing differentiated macrophages stimulated through TLR2.
(last updated: 15 Sept 2020 )
SERP Ratings
(last updated: 6 Jul 2022 )