MCC950

MCC950 : Inhibitor of NLRP3

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(2 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Information

NLRP3

Inhibitor

50 nM
Reviewer recommended concentration: 10-50 mg dose in model organism studies

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Probe Availability:

In Vitro Validations

Uniprot ID: Q96P20

Target Class: Other

Target SubClass: NACHT, LRR and PYD domains-containing Protein

Potency: KD

Potency Value: 224 nM

Potency Assay: SPR

PDB ID for probe-target interaction (3D structure): --

Target aliases:

NACHT, LRR and PYD domains-containing protein 3, P ...

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

MCC950 does not inhibit NLRC4, AIM2, NLRP3 priming or Toll-like receptor signaling

Probe Selectivity in Cell:

MCC950 does not inhibit NLRC4, AIM2, NLRP3 priming or Toll-like receptor signaling

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

This probe has been tested in human primary cell-based assays (BioMAP Diversity PLUS panel from Eurofins Discovery) at 370 – 10 uM. Selectively active in only one of the 12 assay systems at 370 nM, 1.1 uM and 3.3 uM. Activity is restricted to the BioMAP LPS system, a co-culture stimulated with LPS, so consistent with the target. It was not active in a system containing differentiated macrophages stimulated through TLR2.

(last updated: 15 Sept 2020 )

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 6 Jul 2022 )