M5049

M5049 : Inhibitor of TLR7, TLR8

Structure

SERP Rating

Probe M5049 is in the process of SERP review.

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Information

TLR7
TLR8

Inhibitor

up to 10 uM

Probe Availability:

MedChemExpress
MCULE

In Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Within Target Family - Tested in Reaction Biology 389 kinase panel: Kinases inhibited >50% at 1 µMa CAMKK2. Outside target family - CEREP receptor profiling assay: 5-HT uptake. M5049 was profiled in the BioMap (Discover X – Eurofins) Diversity PLUS Panel to assess its activity in a variety of human primary cell co-culture systems. M5049 was tested at concentrations ranging from 10 nM to 10 mM and showed little activity

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No SERP comments found for M5049