Partial Agonist of NR1H2, NR1H3



Protein target names: NR1H2, NR1H3

Mechanism of action: Partial Agonist

In Vitro Validations

Uniprot ID: P55055
Target Class: NHR
Target SubClass: NR1 Subfamily
Potency: IC 50
Potency Value: 179 nM
Potency Assay: Radio Labelled binding assay
PDB ID for probe-target interaction (3D structure): not publ.
Structure-activity relationship: yes
Target aliases:
Oxysterols receptor LXR-beta, UNR, NER, LXRB, NR1H ...

DOI Reference: 10.1021/jm800799q

In Cell Validations

In Vivo Data

I have extra information to add

SERP ratings and comments

SERP Ratings

In Cell Rating

SERP Comments:

This compound is a partial agonist of LXRa making interpretation of its biology in cells very complex. Partial agonists of nuclear receptors do not make good chemical probes. I do not recommend use of this compound.

(last updated: 10 Nov 2020 )

SERP Ratings

In Cell Rating
In Model Organisms

(last updated: 16 Nov 2020 )