Luminespib
Inhibitor of HSP90AA1, HSP90AB1
Structure
In Cells
In Model Organisms
Information
Protein target names: HSP90AA1, HSP90AB1
Mechanism of action: Inhibitor
In Vitro Validations
DOI Reference: 10.1158/1078-0432.CCR-05-0518
In Cell Validations
In Vivo Data
SERP ratings and comments
SERP Ratings
SERP Comments:
AUY922 targets members of the heat shock protein 90 (Hsp90) family. This molecule binds to the N-terminal nucleotide-binding sites of Hsp90s. It is worth noting that there are other possible binding sites and mechanisms for inhibiting this target (e.g. targeting the C-terminal dimerization domain) and the pharmacology associated with these mechanisms may not be equivalent.
(last updated: 3 Jul 2020 )
SERP Ratings
(last updated: 5 Sept 2020 )
SERP Ratings
(last updated: 10 Nov 2020 )