LSN-3213128

Inhibitor of ATIC

Structure

Information

Protein target names: ATIC

Mechanism of action: Inhibitor

Recommended in-cell concentration:
up to 200 nM

In Vitro Validations

Uniprot ID: P31939
Target Class: Other
Target SubClass: formyltransferase and cyclohydrolase
Potency: IC50
Potency Value: 16 ± 11 nM
Potency Assay: Enzymatic Assay
PDB ID for probe-target interaction (3D structure): 5UZ0
Structure-activity relationship: yes
Target aliases:
Bifunctional purine biosynthesis protein ATIC, PUR ...

DOI Reference: 10.1021/acs.jmedchem.7b01046

In Cell Validations

In Vivo Data

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SERP ratings and comments


SERP Ratings

In Cell Rating
In Model Organisms

SERP Comments:

Concentration note: The compound is a straightforward competitive inhibitor. So the inhibitory effect of the compound greatly differs depending on the cellular folate concentration.

(last updated: 4 Aug 2021 )