LS-170

LS-170 : Covalent Inhibitor of YEATS2

Structure

SERP Rating

Probe LS-170 is in the process of SERP review.

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Information

YEATS2

Covalent Inhibitor

up to 20 uM

In Vitro Validations

Uniprot ID: Q9ULM3

Target Class: Epigenetic

Target SubClass: YEATS

Potency: IC50

Potency Value: 140 nM

Potency Assay: ITC

PDB ID for probe-target interaction (3D structure): --

Target aliases:

YEATS domain-containing protein 2, KIAA1197, YEATS ...

DOI Reference: 10.1038/s41589-025-02132-7

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay, off target (cells): Chemical proteomics approach was employed to determine the selectivity profile of LS-170 at the whole-cell proteome level using a photoaffinity probe Photo-LS-170.

Probe Selectivity in Cell:

Among the proteins labeled by Photo-LS-170, only YEATS2 and MBIP were selectively competed by LS-170 at a concentration of 20 μM.

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SERP ratings and comments

No SERP comments found for LS-170