LS-170 |
LS-170 : Covalent Inhibitor of YEATS2
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| YEATS2 |
|
|
up to 20 uM
Selectivity
In Cell Selectivity Assessment
Potency Assay Off-Target:
Chemical proteomics approach was employed to determine the selectivity profile of LS-170 at the whol ...
Selectivity Assessment Description:
Among the proteins labeled by Photo-LS-170, only YEATS2 and MBIP were selectively competed by LS-170 ...
Potency Cellular
In Vitro
YEATS2
Mode of Action: Covalent Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1038/s41589-025-02132-7
Chemical Information
| Molecular Formula | C34H43BrFN5O7S |
| SMILEs | C[C@@H](C(=O)N1CCCCC1)N(C)C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@H](CCCCNC(=O)c1cc2ccc(Br)cc2o1)NS(C)(=O)=O |
| InChI | InChI=1S/C34H43BrFN5O7S/c1-22(33(44)41-17-7-4-8-18-41)40(2)34(45)28(19-23-10-14-26(36)15-11-23)38-31(42)27(39-49(3,46)47)9-5-6-16-37-32(43)30-20-24-12-13-25(35)21-29(24)48-30/h10-15,20-22,27-28,39H,4-9,16-19H2,1-3H3,(H,37,43)(H,38,42)/t22-,27-,28-/m0/s1 |
| Molecular weight | 763.21 Da |
| AlogP | 3.739200000000001 |
| HBond acceptors | 12 |
| HBond donors | 3 |
| Atoms | 92 |