LC-20W

LC-20W : Inhibitor of CES2

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(0 ratings)

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Probe LC-20W is in the process of SERP review.

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Information

CES2

Inhibitor

up to 500 nM

In Vitro Validations

Uniprot ID: O00748

Target Class: Enzyme

Target SubClass: carboxylesterase/lipase

Potency: IC50

Potency Value: 1.6 nM

Potency Assay: Enzymatic inhibition assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Cocaine esterase, ICE, CES2, EST2_HUMAN, hCE-2, CE ...

DOI Reference: 10.1016/j.ejmech.2023.115708

Uniprot ID: O00748

Target Class: Enzyme

Target SubClass: carboxylesterase/lipase

Potency: Ki

Potency Value: 1.4 nM

Potency Assay: Binding kinetics assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Cocaine esterase, ICE, CES2, EST2_HUMAN, hCE-2, CE ...

DOI Reference: 10.1016/j.ejmech.2023.115708

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): In enzymatic assay, LC-20W was 4538-fold more potent against hCES2A compared to hCES1A,

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SERP ratings and comments

SERP Ratings

In Cell Rating

SERP Comments:

While the compound is 4,538 times more potent against hCES2A than hCES1A and SAR exists, broader selectivity profiling is needed. Providing this data could support its suitability as a probe.

(last updated: 22 Aug 2025 )

SERP Ratings

In Cell Rating

(last updated: 22 Aug 2025 )