LC-04-45

LC-04-45 : Molecular Glue of NEK7

Structure

SERP Rating

Probe LC-04-45 is in the process of SERP review.

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Information

NEK7

Molecular Glue

up to 1 uM

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay, off target (cells): Proteome-wide selectivity was evaluated in MOLT-4 cells treated with 1 μM of LC-04-045 or DMSO for 6 h. Only NEK7 was significantly affected by LC-04-045 tratement.

Potency assay, off target (cells): Selectivity against NEK1, NEK2, NEK4, NEK7, NEK10 and NEK11 was assessed via immunoblot in MOLLT4 cells for 6h and showed high selectivity for NEK7.

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SERP ratings and comments

No SERP comments found for LC-04-45