Lapatinib

Inhibitor of EGFR, ERBB2

Structure

Information

Protein target names: EGFR ERBB2

Mechanism of action: Inhibitor

Recommended in-cell concentration:
up to 10 uM
Primary References:

In Vitro Validations

Uniprot ID: P00533
Target Class: Kinase
Target SubClass: RTK
Potency: IC 50
Potency Value: 10.2 nM
Potency Assay: In vitro kinase assay using intracellular kinase domain
PDB ID for probe-target interaction (3D structure): 1XKK
Structure-activity relationship: yes
Target aliases:
Epidermal growth factor receptor, HER1, ERBB1, ERB ...

PMID Reference: 12467226

In Cell Validations

In Vivo Data

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SERP ratings and comments


No SERP comments found for Lapatinib