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KLHL12-In-7k | KLHL12-In-7k : Inhibitor of KLHL12
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
KLHL12
  • Ki:330 nM
  • Kd:480 nM
  • IC50:140 nM
  • IC50:620 nM
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Selectivity was assessed computationally and based on sequence similarities within the family.
Selectivity Assessment Description:
Ten of KLHL family proteins share sequence identity above 35% and are thus considered highly homolog ...

Potency
Cellular
In Vitro

KLHL12

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.5c02931

Chemical Information

Molecular Formula C16H13Cl3N4O
SMILEs Cc1cccc2c1nc(N)n2CC(=O)Nc1c(Cl)cc(Cl)cc1Cl
InChI InChI=1S/C16H13Cl3N4O/c1-8-3-2-4-12-14(8)22-16(20)23(12)7-13(24)21-15-10(18)5-9(17)6-11(15)19/h2-6H,7H2,1H3,(H2,20,22)(H,21,24)
Molecular weight 382.02 Da
AlogP 4.525820000000002
HBond acceptors 5
HBond donors 3
Atoms 37

Expert Reviews

by SERP
(on 6 Apr 2026)
Cellular Use Rating
This entry features the most potent compound from the only series currently known to bind KLHL12. The in vitro binding is well-characterized via high-resolution crystal structures, and nanoBRET assays...
by SERP
(on 20 Apr 2026)
Cellular Use Rating
This is the first small molecule identified for KLHL12 and is therefore the best available. However, it lacks sufficient selectivity analysis to be considered a chemical probe. No data is available to...
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