KISS1-305

Agonist of KISS1R

Structure

SERP Rating

Probe KISS1-305 is in the process of SERP review.

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Information

KISS1R

Agonist

10-1000 nM

Additional Data

SGC image SGC Chemical Probe Collection

In Vitro Validations

Uniprot ID: Q969F8

Target Class: GPCR

Target SubClass: KISS 1 Receptor

Potency: Ki

Potency Value: 0.089 nM

Potency Assay: Biological Activity of Nonapeptide Metastin human analogs

PDB ID for probe-target interaction (3D structure): --

Target aliases:

KiSS-1 receptor, GPR54, AXOR12, KISS1R, KISSR_HUMA ...

DOI Reference: 10.1021/jm401056w

Uniprot ID: Q969F8

Target Class: GPCR

Target SubClass: KISS 1 Receptor

Potency: Ki

Potency Value: 0.10 nM

Potency Assay: Biological Activity of Nonapeptide Metastin rat analogs

PDB ID for probe-target interaction (3D structure): --

Target aliases:

KiSS-1 receptor, GPR54, AXOR12, KISS1R, KISSR_HUMA ...

DOI Reference: 10.1021/jm401056w

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Binding against NPFFR2 (GPR74) and NPFFR1 (GPR147) >30 fold Clean GPCR scan with the exception for OPRD1 (Ki = 47.5 nM, n= 2)

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SERP ratings and comments

No SERP comments found for KISS1-305