KH12

KH12 : Degrader (PROTAC) of METTL3

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(0 ratings)

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Probe KH12 is in the process of SERP review.

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Information

METTL3

Degrader (PROTAC)

1 uM

In Vitro Validations

Uniprot ID: Q86U44

Target Class: Epigenetic

Target SubClass: Methyltransferase

Potency: IC50

Potency Value: 341 nM

Potency Assay: Methyltransferase assay showing inhibition of the METTL3/14 complex

PDB ID for probe-target interaction (3D structure): --

Target aliases:

N6-adenosine-methyltransferase catalytic subunit, ...

DOI Reference: 10.1016/j.ejmech.2024.116843

In Cell Validations

In Vivo Data

No in Vivo Validations

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SERP ratings and comments

SERP+ Ratings

In Cell Rating

SERP+ Comments:

While KH12 has been shown to be a potent degrader of METTL3, there is no indication of degradation selectivity in cells by proteomic studies

(last updated: 31 Oct 2024 )