JZ128 |
JZ128 : Covalent Inhibitor of PKN3
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| PKN3 |
|
|
Covalent Inhibitor
up to 1 uM
Selectivity
In Cell Selectivity Assessment
Potency Assay Off-Target:
Proteome-wide selectivity of JZ128 was assessed in PC3 cells.
Selectivity Assessment Description:
Quantitative, dose-dependent competitive binding data for 686 reproducible JZ128-DTB-labeled cystein ...
In Vitro Selectivity Assessment
Potency Assay Off-Target:
In vitro kinase assays showed JZ128 to have a roughly 200 nM IC50 against SRC and RIPK2.
In Cell Selectivity Assessment
Potency Assay Off-Target:
KiNativ platform was used to interrogate JZ128 with respect to kinase inhibition.
Selectivity Assessment Description:
In total 292 kinases were detected in PC3 cells, with only three showing greater than 50% inhibition ...
Potency Cellular
In Vitro
PKN3
Mode of Action: Covalent Inhibitor
Structure-Activity-Relationship data available? No
DOI Reference: 10.1021/jacs.8b07911
Negative Control Compounds
JZ128-R
SMILES:
CC1=CC=CC2=C1C(C3=NC(NC4=CC(NC(C5=CC=C(NC(CCCN(C)C)=O)C=C5)=O)=CC=C4)=NC=C3)=CN2
Chemical Information
| Molecular Formula | C32H31N7O2 |
| SMILEs | Cc1cccc2[nH]cc(-c3ccnc(Nc4cccc(NC(=O)c5ccc(NC(=O)/C=C/CN(C)C)cc5)c4)n3)c12 |
| InChI | InChI=1S/C32H31N7O2/c1-21-7-4-10-28-30(21)26(20-34-28)27-16-17-33-32(38-27)37-25-9-5-8-24(19-25)36-31(41)22-12-14-23(15-13-22)35-29(40)11-6-18-39(2)3/h4-17,19-20,34H,18H2,1-3H3,(H,35,40)(H,36,41)(H,33,37,38)/b11-6+ |
| Molecular weight | 545.25 Da |
| AlogP | 5.985520000000004 |
| HBond acceptors | 9 |
| HBond donors | 4 |
| Atoms | 72 |