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JV322 | JV322 : Agonist of NR4A1, NR4A2, NR4A3
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NR4A1
  • Kd:100 ± 10 nM
  • EC50:98 ± 7 nM
  • EC50:0.094 µM
NR4A2
    • EC50:92 ± 8 nM
    NR4A3
      • EC50:90 ± 9 nM
      300 - 600 nM

      Selectivity

      In Vitro Selectivity Assessment
      Potency Assay Off-Target:
      JV332 is selective over nuclear receptors outside the NR4A family with moderate DHODH activation at ...

      Potency
      Cellular
      In Vitro

      NR4A1

      Mode of Action: Agonist

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1021/acs.jmedchem.5c03217

      NR4A2

      Mode of Action: Agonist

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1021/acs.jmedchem.5c03217

      NR4A3

      Mode of Action: Agonist

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1021/acs.jmedchem.5c03217

      Negative Control Compounds

      JV339
      Notes: Methylation of the amide linker of JV332 (53) in JV339 (54) abolished activity on all NR4A receptors up to 100 μM corresponding to at least 1000-fold reduced potency.
      SMILES: O=C(O)C1=C(C(N(C)C2=CC=C(C3=C4C(OC(F)(O4)F)=CC=C3)C=C2Cl)=O)CCC1

      Chemical Information

      Coming Soon...

      References

      Publications

      Cross References

      SGC

      Expert Reviews

      No SERP comments found for JV322

      Probe JV322 is in the process of SERP review.

      Please continue to check back for new reviews and commentary.

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