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JP3000

JP3000 : Agonist of RXRA, RXRB, RXRG

Structure

Information

  • RXRA
  • RXRB
  • RXRG
  • Agonist
  • between 100 nM and 1 uM

In Vitro Validations

Uniprot ID: P19793
Target Class: NHR
Target SubClass: Retinoic acid receptor
Potency: IC50
Potency Value: <10 nM
Potency Assay: ITC
PDB ID for probe-target interaction (3D structure): --
Target aliases:
Retinoic acid receptor RXR-alpha, NR2B1, RXRA, RXR ...

Other Reference: Peer reviewed at SGC

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): Tested on 27 related nuclear receptors at 1 µM (in-house panel): clean (> 100 fold selectivity)
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SERP ratings and comments

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