JNJ-79883960

JNJ-79883960 : Inhibitor of NLRP3

Structure

SERP Rating

Probe JNJ-79883960 is in the process of SERP review.

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Information

NLRP3

Inhibitor

up to 10 µM

Additional Data

SGC image SGC Chemical Probe Collection

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Tested some of the other 11 human inflammasomes: A panel of inflammasome triggers was used to look at inhibition (with 10 µM of JNJ-79883960) of the NLRP3, NLRC4, Pyrin, AIM2 and NLRP1b inflammasome. Highly selective for the NLRP3 inflammasome.

Probe Selectivity in Vitro:

All analogs were clean in CEREP and DiscoverX kinase panel

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SERP ratings and comments

No SERP comments found for JNJ-79883960