JNJ-65355394

JNJ-65355394 : Inhibitor of OGA

Structure

SERP Rating

Probe JNJ-65355394 is in the process of SERP review.

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Information

Inhibitor

up to 1 uM

Additional Data

SGC image SGC Chemical Probe Collection

In Vitro Validations

Uniprot ID: O60502

Target Class: Enzyme

Target SubClass: Hydrolase

Potency: IC50

Potency Value: 1.3 nM

Potency Assay: Fluorescence-based enzymatic assay.

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Protein O-GlcNAcase, MGEA5, MEA5, KIAA0679, HEXC, ...

Other Reference: peer reviewed at SGC

Uniprot ID: O60502

Target Class: Enzyme

Target SubClass: Hydrolase

Potency: Ki

Potency Value: 0.035 nM

Potency Assay: Time dependent inhibition: t = 0 (Ki = 1.1 nM); t = 15 min (Ki = 0.035 nM). Kinetic profile: kinact = 0.0036 1/min; kinact/Ki = 3.27 1/(µM*s).

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Protein O-GlcNAcase, MGEA5, MEA5, KIAA0679, HEXC, ...

Other Reference: peer reviewed at SGC

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Selectivity within target family: > 30-fold HEXA IC50 > 10 µM. Selectivity outside target family: CEREP panel (54 targets) at 10 µM: Closest hits are [% inhibition]: rat OPRK1 (78), rat ADORA2A (69); human OPRM1 (55).

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No SERP comments found for JNJ-65355394