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JA397 | JA397 : Inhibitor of CDK14, CDK15, CDK16, CDK17, CDK18 (TAIRE subfamily)
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CDK14
  • EC50:27.1 nM
  • EC50:72.1 nM
CDK15
  • EC50:252 nM
  • EC50:307 nM
CDK16
  • EC50:39.0 nM
  • EC50:33.4 nM
CDK17
  • EC50:77.2
  • EC50:21.2 nM
CDK18
  • EC50:172 nM
  • EC50:121 nM
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Kinome-wide selectivity profile of JA397 was determined in in-house kinase DSF-panel comprising 105 ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
Selectivity within the CDK family was determined by NanoBRET.

Potency
Cellular
In Vitro

CDK14

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.3390/ijms232314834

CDK15

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.3390/ijms232314834

CDK16

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.3390/ijms232314834

CDK17

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.3390/ijms232314834

CDK18

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.3390/ijms232314834

Negative Control Compounds

JA314
Notes: The negative control compound 314 displayed a EC50 value of 4165 nM against CDK16, determined by NanoBRETTM assay, and no stabilization against 105 kinases screened in our in-house DSF-Panel.
SMILES: O=C(NC)C1=CC(NC2=NC(NC3=CC=C(CCNC(OC(C)(C)C)=O)C=C3)=NC=C2)=NN1

Chemical Information

Molecular Formula C24H31N7O4
SMILEs CC(C)(C)OC(=O)Nc1ccc(CNc2nccc(Nc3cc(C(=O)OC(C)(C)C)[nH]n3)n2)cc1
InChI InChI=1S/C24H31N7O4/c1-23(2,3)34-20(32)17-13-19(31-30-17)28-18-11-12-25-21(29-18)26-14-15-7-9-16(10-8-15)27-22(33)35-24(4,5)6/h7-13H,14H2,1-6H3,(H,27,33)(H3,25,26,28,29,30,31)
Molecular weight 481.24 Da
AlogP 4.857700000000003
HBond acceptors 11
HBond donors 4
Atoms 66

Expert Reviews

by SERP
(on 6 Mar 2024)
Cellular Use Rating
(The reviewer did not leave any public comments)
by SERP+
(on 23 Sept 2024)
Cellular Use Rating
(The reviewer did not leave any public comments)
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