ISPINESIB

ISPINESIB : Inhibitor of KIF11

Structure

SERP Rating

Probe ISPINESIB is in the process of SERP review.

Please continue to check back for new reviews and commentary.

Information

KIF11

Inhibitor

150 nM, up to 1 uM

Probe Availability:

In Vitro Validations

Uniprot ID: P52732

Target Class: Motor protein

Target SubClass: Kinesin family

Potency: Ki

Potency Value: 1.7 ± 0.1 nM

Potency Assay: MT-stimulated KSP ATPase activity

PDB ID for probe-target interaction (3D structure): 4A5Y, 4AP0

Target aliases:

Kinesin-like protein KIF11, TRIP5, KNSL1, EG5, KIF ...

DOI Reference: 10.1021/bi702061g

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): At 20 µM inhibitor concentration, more than 10000-fold the Ki for KSP, no inhibitory activity was observed toward the mitotic kinesins CENP-E, RabK6, MCAK, and MKLP1, the ubiquitous kinesin heavy chain (KHC), or toward the neuronal kinesin Kif1A.

I have extra information to add

SERP ratings and comments

No SERP comments found for ISPINESIB