IPP/CNRS-A017

Inhibitor of DHODH

Structure

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In Cells

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In Model Organisms

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Information

DHODH

Inhibitor

up to 100 nM

Additional Data

SGC image SGC Chemical Probe Collection

Probe Availability:

In Vitro Validations

Uniprot ID: Q02127

Target Class: Enzyme

Target SubClass: Class 2 Dihydroorotate dehydrogenase

Potency: IC50

Potency Value: 25 nM

Potency Assay: Activity assay

PDB ID for probe-target interaction (3D structure): 6SYP

Target aliases:

Dihydroorotate dehydrogenase (quinone), mitochondr ...

DOI Reference: 10.1021/acs.jmedchem.5b00606

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): Selectivity outside target family: GPCR screen (44 targets): Closest off-targets at 10 µM are GABA/ PBR (KD =2.1 µM), ADRA1D (KD = 4.1 µM) and TMEM97 (KD = 583 nM) PDSP GPCR screen: Closest off-targets are TMEM97 (83.71 % inhibition), ADRA2A (77.67 % inhibition), GABA/PBR (62.49 % inhibition) and ADRB3 (Ki = 5327.21 nM). Clean KINOMEscan.

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SERP+ Ratings

In Cell Rating

(last updated: 23 Sept 2024 )