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IOX2 | IOX2 : Inhibitor of EGLN1
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
EGLN1
  • IC50:22 nM
  • INH:250 nM
  • Activity:50 nM
1 µM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
IOX2 was profiled against a panel of human histone Nε-methyl lysine demethylase 2OG-oxygenases in an ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
Selective inhibition of IOX2 in human cell lines. Selectivity of the tested inhibitors for HIF-1α pr ...
In Vitro Selectivity Assessment
Potency Assay Off-Target:
IOX2 was tested against a panel of other human 2OG oxygenases focusing on histone Nε-methyl lysine d ...

Potency
Cellular
In Vitro

EGLN1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1007/s00204-015-1549-y

Chemical Information

Molecular Formula C19H16N2O5
SMILEs O=C(O)CNC(=O)c1c(O)c2ccccc2n(Cc2ccccc2)c1=O
InChI InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
Molecular weight 352.11 Da
AlogP 1.5698
HBond acceptors 7
HBond donors 3
Atoms 42

Vendors

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Expert Reviews

No SERP comments found for IOX2

Probe IOX2 is in the process of SERP review.

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