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Portal Publications

List of Papers Published by The Portal Team

  1. Arrowsmith, C.H., Audia, J.E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P.E., Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ. (2015). The promise and peril of chemical probes. Nat Chem Biol 11, 536-541. 10.1038/nchembio.1867.

  2. Blagg, J., and Workman, P. (2017). Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology. Cancer Cell 32, 268-270. 10.1016/j.ccell.2017.07.010.

  3. Muller, S., Ackloo, S., Arrowsmith, C.H., Bauser, M., Baryza, J.L., Blagg, J., Bottcher, J., Bountra, C., Brown, P.J., Bunnage, M.E., Carter, A.J., Damerell D., Dötsch V., Drewry D.H., Edwards AM, Edwards J., Elkins J.M., Fischer C., Frye, S.V., Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, MJ Li V, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan R.C., Owen D.R., Pande V., Rauh D., Rosenberg S.H., Roth B.L., Schneider N.S., Scholten C., Saikatendu KS, Simeonov A., Takizawa M., Tse C., Thompson PR, Treiber DK, Viana A.Y., Wells CI, Willson T.M., Zuercher W.J., Knapp S., Mueller-Fahrnow A (2018). Donated chemical probes for open science. Elife 7. 10.7554/eLife.34311.

  4. Antolin, A.A., Workman, P., and Al-Lazikani, B. (2021). Public resources for chemical probes: the journey so far and the road ahead. Future Med Chem 13, 731-747. 10.4155/fmc-2019-0231.

  5. A conversation on using chemical probes to study protein function in cells and organisms. (2022). Nat Commun 13, 3757. Featuring Workman P and Arrowsmith C. 10.1038/s41467-022-31271-x.

  6. Licciardello, M.P., and Workman, P. (2022). The era of high-quality chemical probes. RSC Med Chem 13, 1446-1459. 10.1039/d2md00291d.

  7. Müller S, Ackloo S, Al Chawaf A, Al-Lazikani B, Antolin A, Baell JB, Beck H, Beedie S, Betz UAK, Bezerra GA, Brennan PE, Brown D, Brown PJ, Bullock AN, Carter AJ, Chaikuad A, Chaineau M, Ciulli A, Collins I, Dreher J, Drewry D, Edfeldt K, Edwards AM, Egner U, Frye SV, Fuchs SM, Hall MD, Hartung IV, Hillisch A, Hitchcock SH, Homan E, Kannan N, Kiefer JR, Knapp S, Kostic M, Kubicek S, Leach AR, Lindemann S, Marsden BD, Matsui H, Meier JL, Merk D, Michel M, Morgan MR, Mueller-Fahrnow A, Owen DR, Perry BG, Rosenberg SH, Saikatendu KS, Schapira M, Scholten C, Sharma S, Simeonov A, Sundström M, Superti-Furga G, Todd MH, Tredup C, Vedadi M, von Delft F, Willson TM, Winter GE, Workman P, Arrowsmith CH. (2022). Target 2035 - update on the quest for a probe for every protein. RSC Med Chem 13, 13-21. 10.1039/d1md00228g.

  8. Heinzlmeir, S., and Muller, S. (2022). Selectivity aspects of activity-based (chemical) probes. Drug Discov Today 27, 519-528. 10.1016/j.drudis.2021.10.021.

  9. Hartung, I.V., Rudolph, J., Mader, M.M., Mulder, M.P.C., and Workman, P. (2023). Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes. J Med Chem 66, 9297-9312. 10.1021/acs.jmedchem.3c00550.

  10. Mader, M.M., Rudolph, J., Hartung, I.V., Uehling, D., Workman, P., and Zuercher, W. (2023). Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation. Cancer Discov 13, 2150-2165. 10.1158/2159-8290.CD-23-0536.

  11. Hu, H., Tjaden, A., Knapp, S., Antolin, A.A., and Muller, S. (2023). A machine learning and live-cell imaging tool kit uncovers small molecules induced phospholipidosis. Cell Chem Biol 30, 1634-1651 e1636. 10.1016/j.chembiol.2023.09.003.

  12. Antolin, A.A., Sanfelice, D., Crisp, A., Villasclaras Fernandez, E., Mica, I.L., Chen, Y., Collins, I., Edwards, A., Muller, S., Al-Lazikani, B., and Workman, P. (2023). The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use. Nucleic Acids Res 51, D1492-D1502. 10.1093/nar/gkac909.

  13. Knapp, S., and Muller, S. (2023). Improving data quality in chemical biology. Nat Chem Biol 19, 1301-1302. 10.1038/s41589-023-01449-5.

  14. Sanfelice, D., Antolin, A.A., Crisp, A., Chen, Y., Bellenie, B., Brennan, P.E., Edwards, A., Muller, S., Al-Lazikani, B., and Workman, P. (2025). The Chemical Probes Portal - 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research. Nucleic Acids Res 53, D1663-D1669. 10.1093/nar/gkae1062.

  15. Muller, S., Sanfelice, D., and Workman, P. (2025). Probing cancer with small-molecule tools-Progress and challenges. Cancer Cell 43, 323-327. 10.1016/j.ccell.2025.02.003.

Contributions to Partner Resources Probe Miner and canSAR

  1. Antolin, A.A., Tym, J.E., Komianou, A., Collins, I., Workman, P., and Al-Lazikani, B. (2018). Objective, Quantitative, Data-Driven Assessment of Chemical Probes. Cell Chem Biol 25, 194-205 e195. 10.1016/j.chembiol.2017.11.004.

  2. Coker, E.A., Mitsopoulos, C., Tym, J.E., Komianou, A., Kannas, C., Di Micco, P., Villasclaras Fernandez, E., Ozer, B., Antolin, A.A., Workman, P., and Al-Lazikani, B. (2019). canSAR: update to the cancer translational research and drug discovery knowledgebase. Nucleic Acids Res 47, D917-D922. 10.1093/nar/gky1129.

  3. Mitsopoulos, C., Di Micco, P., Fernandez, E.V., Dolciami, D., Holt, E., Mica, I.L., Coker, E.A., Tym, J., Campbell J, Che KH, Ozer B, Kannas C, Antolin AA, Workman P, Al-Lazikani B (2021). canSAR: update to the cancer translational research and drug discovery knowledgebase. Nucleic Acids Res 49, D1074-D1082. 10.1093/nar/gkaa1059.

  4. di Micco, P., Antolin, A.A., Mitsopoulos, C., Villasclaras-Fernandez, E., Sanfelice, D., Dolciami D, Ramagiri P, Mica IL, Tym JE, Gingrich PW, Hu H, Workman P, Al-Lazikani B. (2023). canSAR: update to the cancer translational research and drug discovery knowledgebase. Nucleic Acids Res 51, D1212-D1219. 10.1093/nar/gkac1004.