INCB085660

INCB085660 : inhibitor of PD-L1

Structure

Information

  • CD274
  • PPI
  • 200 nM

In Vitro Validations

Uniprot ID: Q9NZQ7
Target Class: Receptor ligand
Target SubClass: Cell death receptor ligand
Potency: IC50
Potency Value: 3.1 nM
Potency Assay: Homogeneous time-resolved fluorescence (HTRF)–based PD-L1/PD-1 interaction assay
PDB ID for probe-target interaction (3D structure): --
Target aliases:
Programmed cell death 1 ligand 1, PDL1, PDCD1LG1, ...

DOI Reference: 10.1158/2159-8290.CD-21-1156

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Selectivity within target family: PD-L2 IC50 > 10uM
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SERP ratings and comments


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