IMP-1088
Inhibitor of NMT1, NMT2
Structure
In Cells
In Model Organisms
Information
Protein target names: NMT1, NMT2
Mechanism of action: Inhibitor
In Vitro Validations
DOI Reference: 10.1016/j.chembiol.2019.03.006
DOI Reference: 10.1016/j.chembiol.2019.03.006
In Cell Validations
In Vivo Data
No in Vivo Validations
SERP ratings and comments
SERP Ratings
Comments:
The cited reference (10.1016/j.chembiol.2019.03.006) is an excellent comparative study of the 5 cmpds that have been used as NMT probes and shows clearly and conclusively that only IMP-1088 and IMP-366 ( DDD85646 ) are suitable to use as orthogonal probes in vitro and in cells for the human NMT1 and NMT2 targets. Of these two, IMP-1088 is clearly the more potent probe cmpd.
(last updated: 18 Jun 2021 )
SERP Ratings
Comments:
Proteomic data suggest that this compound has high specificity for NMT1 and NMT2, but genetic evidence for target specificity is still awaited. There is no information on its usefulness in animal models.
(last updated: 30 Jun 2021 )
SERP Ratings
Comments:
There is no selectivity data indicating that this compound inhibits the intended target(s) without inhibiting other acyltransferases. Looking at the chemical structure, I would anticipate activity on other target classes outside of the acyltransferases. In addition, there is no negative control compound that would raise the comfort level of using this compound as a chemical probe.
(last updated: 7 Jul 2021 )