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ICI-199441 | Agonist of OPRK1
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
OPRK1
  • Ki:0.04 nM
  • EC50 :0.3 nM
Agonist
up to 100 nM

Selectivity

In Vitro Selectivity Assessment

Potency: Ki - OPRD1: 24 nM, OPRM1: 53 nM, UTS2R: 4,000 nM

Potency Assay Off-Target:
Measured using [3H]-diprenorphine as radioligand in binding assay (OPRD1, OPRM1) reported in Bioorg. ...
Selectivity Assessment Description:
CYP2D6 IC50 = 26 nM

Potency
Cellular
In Vitro

OPRK1

Mode of Action: Agonist

Structure-Activity-Relationship data available? No

In Vivo Validations

Rat, Mouse (J Med Chem paper, no PK data published)
Dose: 10 mg/kg
Route of delivery: Subcutaneous, Intrapaw
Organ of interest (O): CNS, PNS
Target engagement assay: Formalin flinching (A50 when administered via paw: 0.74 ug; A50 when administered sc: 0.05 mg/kg) and rotarod (ED50 sc=0.14 mg/kg) assays indirecly indicate interaction with target in both CNS and PNS.

Reference: --

Orthogonal Probes def

Salvinorin A

Chemical Information

Molecular Formula C21H24Cl2N2O
SMILEs CN(C(=O)Cc1ccc(Cl)c(Cl)c1)[C@H](CN1CCCC1)c1ccccc1
InChI InChI=1S/C21H24Cl2N2O/c1-24(21(26)14-16-9-10-18(22)19(23)13-16)20(15-25-11-5-6-12-25)17-7-3-2-4-8-17/h2-4,7-10,13,20H,5-6,11-12,14-15H2,1H3/t20-/m1/s1
Molecular weight 390.13 Da
AlogP 4.831400000000004
HBond acceptors 3
HBond donors --
Atoms 50

References

Publications

Cross References

Vendors

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Expert Reviews

by SERP
(on 19 May 2020)
Cellular Use Rating
In Model Organisms
Opioid agonist signalling is complex and context dependent. This makes probe definitions complicated. This compound is a very potent kappa opioid agonist with opioid receptor subtype selectivity in...
by SERP
(on 16 Nov 2020)
Cellular Use Rating
In Model Organisms
Recommended dose for in vivo studies is high when considered in light of the high potency in cell-based assays and the Ki. As a result interpretation of a target specific role in any biological impact...
by SERP
(on 16 Nov 2020)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
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