Ibrutinib
Covalent Inhibitor of BTK
Structure
Probe Ibrutinib is in the process of SERP review.
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Information
Protein target names: BTK
Mechanism of action: Covalent Inhibitor
Recommended in-cell concentration:
10 nM
Primary References:
Probe Availability:
In Vitro Validations
Uniprot ID: Q06187
Target Class:
Kinase
Target SubClass: --
Potency: IC50
Potency Value: 0.5 nM
Potency Assay: IC50s were measured using 33P filtration binding assay
PDB ID for probe-target interaction (3D structure):
5P9J
Target aliases:
Tyrosine-protein kinase BTK, AGMX1, BTK, BTK_HUMAN ...
DOI Reference: 10.1073/pnas.1004594107
In Cell Validations
In Vivo Data
SERP ratings and comments
No SERP comments found for Ibrutinib