Ibrutinib

Covalent Inhibitor of BTK

Structure

Information

Protein target names: BTK

Mechanism of action: Covalent Inhibitor

Recommended in-cell concentration:
10 nM

In Vitro Validations

Uniprot ID: Q06187
Target Class: Kinase
Target SubClass: --
Potency: IC50
Potency Value: 0.5 nM
Potency Assay: IC50s were measured using 33P filtration binding assay
PDB ID for probe-target interaction (3D structure): 5P9J
Target aliases:
Tyrosine-protein kinase BTK, AGMX1, BTK, BTK_HUMAN ...

DOI Reference: 10.1073/pnas.1004594107

In Cell Validations

In Vivo Data

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SERP ratings and comments


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