HPK1-IN-3

HPK1-IN-3 : ATP-competitive of MAP4K1

Structure

SERP Rating

Probe HPK1-IN-3 is in the process of SERP review.

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Information

MAP4K1

ATP competitive

up to 1 uM

Probe Availability:

MedChemExpress

In Vitro Validations

Uniprot ID: Q92918

Target Class: Kinase

Target SubClass: STE

Potency: IC50

Potency Value: 0.25 nM

Potency Assay: HPK1 Biochemical Assay (TR-FRET)

PDB ID for probe-target interaction (3D structure): 7M0M

Target aliases:

Mitogen-activated protein kinase kinase kinase kin ...

DOI Reference: 10.1021/acsmedchemlett.1c00096

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Selectivity within target family: Improved kinome selectivity for HPK1-IN-3 (>100× selectivity in 252/265 kinases examined). MAP4K2/3/4 fold-selective 1150x/4x/3423x JAK1/2/3 fold-selective 1072x/262x/136x FTL3 fold-selective >10000x LCK fold-selective >10000x

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SERP ratings and comments

No SERP comments found for HPK1-IN-3