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HDAC2-In-11 | HDAC2-In-11 : Inhibitor of HDAC2
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
HDAC2
  • IC50:14 nM
  • Inhibition:Imax 71%
up to 1 uM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
Selectivity against HDAC1: Evaluation of H3K9 acetylation in HDAC2-KO K562 cells, showing an Imax of ...

Potency
Cellular
In Vitro

HDAC2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acs.jmedchem.5c02022

In Vivo Validations

Rat
Dose: not revealed
Route of delivery: Intravenous
Bioavailability: Total brain-to-plasma ratio: 0.93
Organ of interest (O): brain

DOI Reference: 10.1021/acs.jmedchem.5c02022

Chemical Information

Molecular Formula C19H16N6OS
SMILEs Cn1cc(-c2cnc(C(=O)Nc3cc(-c4cccs4)ccc3N)cn2)cn1
InChI InChI=1S/C19H16N6OS/c1-25-11-13(8-23-25)16-9-22-17(10-21-16)19(26)24-15-7-12(4-5-14(15)20)18-3-2-6-27-18/h2-11H,20H2,1H3,(H,24,26)
Molecular weight 376.11 Da
AlogP 3.440100000000001
HBond acceptors 7
HBond donors 3
Atoms 43

Expert Reviews

by SERP
(on 14 Apr 2026)
Cellular Use Rating
In Model Organisms
While a cellular selectivity assay was used in the original report (HDAC2-KO K562 cells) and the results appear promising, the wider selectivity of this compound could be more well characterized. Confidence...
by SERP
(on 1 May 2026)
Cellular Use Rating
In Model Organisms
This compounds shows a window of selectivity between HDAC2 and HDAC1 for inhibition, but has not been tested more broadly against all HDAC family members. It shows activity in vitro as well as in vivo,...
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