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HDAC2-In-11

HDAC2-In-11 : Inhibitor of HDAC2

Structure

Information

  • HDAC2
  • Inhibitor
  • up to 1 uM

In Vitro Validations

Uniprot ID: Q92769
Target Class: Epigenetic
Target SubClass: HDAC
Potency: IC50
Potency Value: 14 nM
Potency Assay: Biochemical HTRF assay using recombinant enzyme HDAC2
PDB ID for probe-target interaction (3D structure): --
Target aliases:
Histone deacetylase 2, HDAC2, HDAC2_HUMAN, HD2, Pr ...

DOI Reference: 10.1021/acs.jmedchem.5c02022

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay, off target (cells): Selectivity against HDAC1: Evaluation of H3K9 acetylation in HDAC2-KO K562 cells, showing an Imax of 11%.
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SERP ratings and comments

No SERP comments found for HDAC2-In-11