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hCAII Degrader 11 | Degrader (PROTAC) of CA2
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
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Potency
In Vivo
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Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CA2
    • DC50:0.5 ± 0.3 nM
    • Dmax:100%
    up to 100 nM, no 'hook effect' up to 15 uM

    Selectivity

    Potency
    Cellular
    In Vitro

    CA2

    Mode of Action: Degrader (PROTAC)

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1021/acs.jmedchem.2c01843

    Chemical Information

    Molecular Formula C32H41N5O7S
    SMILEs NS(=O)(=O)c1ccc(C(=O)NCCCCCCCCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)cc1
    InChI InChI=1S/C32H41N5O7S/c33-45(43,44)23-16-14-22(15-17-23)29(39)35-21-10-8-6-4-2-1-3-5-7-9-20-34-25-13-11-12-24-28(25)32(42)37(31(24)41)26-18-19-27(38)36-30(26)40/h11-17,26,34H,1-10,18-21H2,(H,35,39)(H2,33,43,44)(H,36,38,40)
    Molecular weight 639.27 Da
    AlogP 3.4781000000000004
    HBond acceptors 12
    HBond donors 5
    Atoms 86

    Expert Reviews

    by SERP
    (on 20 Feb 2025)
    Cellular Use Rating
    This is a very potent hCAII degrader, but no biochemical or cellular selectivity has been measured. It cannot be excluded that other proteins are degraded so should be used with caution.
    If you would like to explore AI-generated evaluations, you may wish to visit the page for this compound on our collaborator website
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria