GW869516X

GW869516X : Inhibitor of CSNK2A1, CSNK2A2

Structure

SERP Rating

In Cells

(1 ratings)

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Probe GW869516X is in the process of SERP review.

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Information

CSNK2A1
CSNK2A2

Inhibitor

up to 1 uM

In Vitro Validations

Uniprot ID: P68400

Target Class: Kinase

Target SubClass: Ser/Thr kinase

Potency: IC50

Potency Value: 85.1 nM

Potency Assay: Biochemical assay

PDB ID for probe-target interaction (3D structure): 7ZWE

Target aliases:

Casein kinase II subunit alpha, CK2A1, CSNK2A1, CS ...

DOI Reference: 10.1038/s41589-023-01459-3

Uniprot ID: P68400

Target Class: Kinase

Target SubClass: Ser/Thr kinase

Potency: Kd

Potency Value: 78 nM

Potency Assay: Kinobead assay

PDB ID for probe-target interaction (3D structure): 7ZWE

Target aliases:

Casein kinase II subunit alpha, CK2A1, CSNK2A1, CS ...

DOI Reference: 10.1038/s41589-023-01459-3

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): A previous study reported more than 70% inhibition of binding of 33 kinases in a broad KINOMEscan assay (covering 468 kinases) for this compound. Only CSNK2A1 and CSNK2A2 were confirmed as targets using Kinobeads, 20 kinases showed no inhibition of binding and 11 kinases were not detected in the Kinobeads assay Screened against a panel of 49 kinase, and analysed via Kinobeads.

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(last updated: 2 Jan 2025 )