GW1100
Selective antagonist of FFAR1
Structure
In Cells
(1
ratings)
In Model Organisms
(1
ratings)
Probe GW1100 is in the process of SERP review.
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SERP ratings and comments
SERP Ratings
In Cell Rating
In Model Organisms
SERP Comments:
GW1100 is a standard cellular and in vivo tool for antagonizing FFAR1/GPR120. It is commonly used to counteract the affects of GPR120 agonist GW9508 and long chain fatty acids. However, the in vivo mouse work in the referenced paper does not consider body weight of the mouse, only that 10ug of material was injected. In one rat study, GW1100 was applied intranasally, although the methods section does not detail the dose. https://doi.org/10.1186/s12974-021-02209-9
(last updated: 4 Dec 2021 )