GW0742

GW072 : Agonist of PPARD

Structure

SERP Rating

Probe GW0742 is in the process of SERP review.

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Information

PPARD

Agonist

up to 1 uM

Probe Availability:

Selleck Chemicals

In Vitro Validations

Uniprot ID: Q03181

Target Class: Nuclear Hormone Receptor

Target SubClass: Nuclear Receptor 1C2

Potency: Kd

Potency Value: 0.4 nM

Potency Assay: competitive TR-FRET assay

PDB ID for probe-target interaction (3D structure): 3TKM

Target aliases:

Peroxisome proliferator-activated receptor delta, ...

DOI Reference: 10.1021/jm3013272

Uniprot ID: Q03181

Target Class: Nuclear Hormone Receptor

Target SubClass: Nuclear Receptor 1C2

Potency: IC50

Potency Value: 1 nM

Potency Assay: Inhibition of human PPARD

PDB ID for probe-target interaction (3D structure): 3TKM

Target aliases:

Peroxisome proliferator-activated receptor delta, ...

DOI Reference: 10.1016/s0960-894x(03)00207-5

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay, off target (cells): Selective in the transient transactivation assay against the other 2 human PPAR subtypes: 1100 nM EC50 PPARA, 2000 nM EC50 PPARG

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SERP ratings and comments

No SERP comments found for GW0742