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GT949

Noncompetitive Positive Allosteric Modulator of SLC1A2

Structure

Information

  • SLC1A2
  • Noncompetitive Positive Allosteric Modulator
  • up to 10 nM

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Probe Selectivity in Cell:

GT949 demonstrated selectivity to EAAT2 and had no effect on glutamate activity mediated by EAAT1 or EAAT3.

Outside Target Family: Exhibits no significant effect on DAT, SERT and NET or NMDA receptors

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SERP ratings and comments

No SERP comments found for GT949