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GSK902056A | GSK902056A : Inhibitor of PKN3
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
PKN3
  • Kd:1 nM
  • IC50:79 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Selectivity was assessed over 278 Kinases using Kinobeads

Potency
Cellular
In Vitro

PKN3

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1038/s41589-023-01459-3

Chemical Information

Molecular Formula C17H21N7O3
SMILEs CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(OCCN)cc21
InChI InChI=1S/C17H21N7O3/c1-4-24-11-9-12(26-8-7-18)20-10(5-6-17(2,3)25)13(11)21-16(24)14-15(19)23-27-22-14/h9,25H,4,7-8,18H2,1-3H3,(H2,19,23)
Molecular weight 371.17 Da
AlogP 0.5433000000000004
HBond acceptors 10
HBond donors 5
Atoms 48

References

Publications

Cross References

Expert Reviews

by SERP
(on 24 Feb 2025 )
Cellular Use Rating
The probe is potent and highly selective for PKN3 (Kinobeads Kd(app) = 1 nM, In-cell NanoBRET target engagement (TE) Kd(app) = 79 nM). Based on the nanoBRET TE data, the probe inhibits (binds) intracellular...
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