ATP competitive inhibitor of RIPK2
Protein target names: RIPK2
Mechanism of action: ATP competitive inhibitor
Recommended in-cell concentration:
In Vitro Validations
Uniprot ID: O43353
Target Class: Kinase
Target SubClass: TKL
Potency Value: 5 nM
Potency Assay: A fluorescent polarization based binding assay was developed to quantitate interaction of novel test compounds at the ATP binding pocket of RIPK2 by competition with a fluorescently labeled ATP competitive ligand.
PDB ID for probe-target interaction (3D structure): 5J7B
Structure-activity relationship: See J. Med. Chem. 2016, 59, 4867−4880.
Receptor-interacting serine/threonine-protein kina ...
DOI Reference: 10.1021/acs.jmedchem.6b00211
In Cell Validations
In Vivo Data
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